Identification and modelling of fast and slow I h current components in vestibular ganglion neurons
نویسندگان
چکیده
منابع مشابه
Identification and modelling of fast and slow Ih current components in vestibular ganglion neurons.
Previous experimental data indicates the hyperpolarization-activated cation (Ih) current, in the inner ear, consists of two components [different hyperpolarization-activated cyclic nucleotide-gated (HCN) subunits] which are impossible to pharmacologically isolate. To confirm the presence of these two components in vestibular ganglion neurons we have applied a parameter identification algorithm ...
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Molecular identity , ontogeny , and cAMP modulation of the hyperpolarization - activated 1 current in vestibular ganglion neurons
1 current in vestibular ganglion neurons. 12 AA and EL made the electrophysiological recordings. FM made the PCR analysis. ES 13 and RV did the immunohistochemical experiments. Abstract 29 Properties, developmental regulation and cAMP modulation of the hyperpolarization
متن کاملMolecular identity, ontogeny, and cAMP modulation of the hyperpolarization-activated current in vestibular ganglion neurons.
Properties, developmental regulation, and cAMP modulation of the hyperpolarization-activated current (I(h)) were investigated by the whole cell patch-clamp technique in vestibular ganglion neurons of the rat at two postnatal stages (P7-10 and P25-28). In addition, by RT-PCR and immunohistochemistry the identity and distribution of hyperpolarization-activated and cyclic nucleotide-gated channel ...
متن کاملIdentity, expression and functional role of the sodium-activated potassium current in vestibular ganglion afferent neurons.
Vestibular afferent neurons (VANs) transmit information from the vestibular end organs to the central nuclei. This information is encoded within the firing pattern of these cells and is heavily influenced by the K⁺ conductances expressed by vestibular neurons. In the present study, we describe the presence of a previously unidentified Na⁺-activated K⁺ conductance (KNa) in these cells. We observ...
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ژورنال
عنوان ژورنال: European Journal of Neuroscience
سال: 2015
ISSN: 0953-816X,1460-9568
DOI: 10.1111/ejn.13021